Abstract
The binding characteristics of [ 3H]idazoxan and [ 3H]rauwolscine, two potent α 2-adrenoceptor antagonists, were compared in the rabbit urethral smooth muscle. The maximal binding capacity was 6 times higher for [ 3H]idazoxan than for [ 3H]rauwolscine in male rabbits. No difference was observed for these radioligands in female rabbits. There were marked differences in the ability of α 2-adrenergic compounds to inhibit [ 3H]idazoxan and [ 3H]rauwolscine binding. These results were consistent with the existence of non- α 2-adrenoceptor sites for [ 3H]idazoxan in the rabbit urethral smooth muscle.
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