Abstract
The existence of long-lived lipid components in developing mice has been demonstrated through the use of separate 14C and 3H acetate injections followed by the measurement of residual labels in the five months following injection. Brain and muscle, among ten tissues examined, contain relative isotope retention ratio (RIR) levels which indicate that some lipids of these tissues are long-lived. Polar as well as non-polar lipids separated by thin layer chromatography which showed such high RIR's included (in order of decreasing RIR values): sulfatides, cerebrosides, phosphatidyl ethanolamine, cardiolipin, cholesterol. Muscle cholesterol has a four-fold lower value than brain, yet was still four times higher in its ratio than those observed with homogenates of other tissues.
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