Abstract
In an experiment designed to test one parameter of the antigenic potential of the hydrogel soft contact lens material polymacon (delayed hypersensitivity as shown by skin test), we divided 20 guinea pigs into four groups of 5. 5 guinea pigs were immunized with ground polymacon in complete Freund’s adjuvant. These animals and 5 uninjected control animals were skin-tested with the same lens material. As a positive control, another 5 animals were immunized with bovine serum albumin in complete Freund’s adjuvant. These animals and 5 uninjected control animals were skin-tested with bovine serum albumin. Only the animals immunized and skin-tested with bovine serum albumin had positive skin-test results for delayed hypersensitivity. The lens material was tolerated without inflammation in immunized and nonimmunized skin-tested animals. There was no histologic evidence for antigenicity of polymacon in guinea pig tissues. We conclude that polymacon is unlikely to act as an antigen for delayed hypersensitivity in the guinea pig. We suggest that conjunctivitis associated with the wearing of polymacon lenses is not caused by antigenicity of the lens itself, but by that of some material adhering to the lens.
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