Abstract
The enterotoxin of Clostridium perfringens is responsible for the symptoms of human food poisoning caused by this organism. The enterotoxin exerts several different biological activities, namely, erythemal activity [1,2], ileal loop activity [2,3] and lethality [2,3]. The toxin has been purified and characterized as a heat-labile protein with an M~ of 36000 ± 4000 [3]. Details of the pathophysiological response of ligated intestinal loop to C. perfringens enterotoxin have been reported [4-8] but intestinal absorption of the enterotoxin has not been studied. In a previous study, we characterized the response of the ligated mouse intestine to C. perfringens enterotoxin [9] and found that inoculation of a large dose of the enterotoxin into ligated intestinal loop was frequently lethal. This suggested that C. perfringens enterotoxin might have passed through the gut wall into the blood circulation. The present work was undertaken to investigate the possible absorption of C. perlringens enterotoxin in the rat intestine. 2.1. Purification of enterotoxin
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