Evidence for intermediates and a change in rate-limiting step in the aminolysis of the carcinogen N-methyl-N'-nitro-N-nitrosoguanidine by cyclic amines

Abstract

Rate constants and products are reported for the decomposition of N-methyl-N'-nitro-N-nitrosoguanidine (M stimulated by cyclic amines in aqueous solutions at 40 o C, ionic strength 1 M (KCl). Plots of κ obs against nucleophile are linear to a concentration of nucleophile up to 0.3 M. The slopes of the plots change as a function of pH. There is no evidence of significant buffer catalysis of the reactions in control experiments containing up to 0.5 M buffer