Abstract
Three inhibitors of the release or effects of endothelium-derived relaxing factor (EDRF), N-nitro- l-arginine, methylene blue and oxyhemoglobin, caused further increases in perfusion pressure during vascular constriction with submaximal concentrations of the thromboxaneA 2-mimetic, U46619 in fetal vessels ofhuman placental lobules perfused in vitro. The results suggest the EDRF, released during constriction of fetal placental vessels in response to thromboxaneA 2 receptor stimulation, attenuates the vasoconstrictor response. Hence, impairment of EDRF release or function could contribute to the reduced placental blood flow observed in various disease states associated with increased thromboxaneA 2 production such as pre-eclampsia.
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