Abstract
BackgroundIt is believed that HPV infection can result in the death of placental trophoblasts and cause miscarriages or preterm birth. In clinical cases of placental villi positive for HPV DNA reported by other authors, contamination is suspected in the act of crossing the cervical canal. We analyzed placental samples of women who resorted to elective abortion obtained by hysterosuction of ovular material, bypassing any contact with the cervical canal and vagina.MethodsWe studied the chorionic villi of the placenta of 64 women who resorted to voluntary termination of pregnancy, in the first trimester. To avoid contamination of the villi by the cervical canal, we analyzed placental samples obtained by hysterosuction of ovular material, bypassing any contact with the cervical canal and vagina. All samples of chorionic villi were manually selected from the aborted material and subjected to research for HPV DNA.ResultsHPV DNA was detected in 10 out of 60 women (16.6%). The HPV DNA identified in the placenta belonged to genotypes 6, 16, 35, 53, and 90.ConclusionThe study shows that papillomavirus DNA can infect the placenta and that placenta HPV infection can occur as early as the first trimester of pregnancy.
Highlights
It is believed that Human papillomavirus infection (HPV) infection can result in the death of placental trophoblasts and cause miscarriages or preterm birth
Trophoblast cells play a crucial role in the placentation process [8] and it is believed that HPV infection can result in the death of placental trophoblasts and cause miscarriages or preterm birth [9]
We investigated the presence of HPV in the placenta of women in the first trimester of pregnancy, who asked for termination of pregnancy (TOP), in order to verify the hypothesis that the placenta may be infected with HPV and that this manifests as early as the first trimester of pregnancy
Summary
It is believed that HPV infection can result in the death of placental trophoblasts and cause miscarriages or preterm birth. It was discovered that the HPV virus is capable of infecting trophoblast cells as well as squamous cells [7]. This discovery adding further support to the proposed association between HPV infection and miscarriage. Trophoblast cells play a crucial role in the placentation process [8] and it is believed that HPV infection can result in the death of placental trophoblasts and cause miscarriages or preterm birth [9]
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