Abstract
Background Wheat is one of the most important food allergen sources. Using natural wheat allergen extracts for serological diagnosis of wheat-induced food allergy false positive test results are frequently obtained, in particular in grass pollen allergic patients. Therefore, Tri a 19, an omega-5-gliadin, which is known as a major allergen in wheat dependent exercise induced anaphylaxis (WDEIA) and in wheat food allergy in children, is widely used for the serological diagnosis of wheat-induced food allergy.
Highlights
Wheat is one of the most important food allergen sources
Tri a 19, an omega-5-gliadin, which is known as a major allergen in wheat dependent exercise induced anaphylaxis (WDEIA) and in wheat food allergy in children, is widely used for the serological diagnosis of wheat-induced food allergy
We compared recombinant Tri a 36 with ImmunoCAPs containing omega-5-gliadin for the detection of specific IgE antibodies in a population of wheat food allergic children (n=23) and grass pollen allergic patients (n=21)
Summary
Evidence for higher sensitivity of recombinant Tri a 36 compared to omega-5-gliadin for diagnosis of wheat food allergy Using natural wheat allergen extracts for serological diagnosis of wheat-induced food allergy false positive test results are frequently obtained, in particular in grass pollen allergic patients. Tri a 19, an omega-5-gliadin, which is known as a major allergen in wheat dependent exercise induced anaphylaxis (WDEIA) and in wheat food allergy in children, is widely used for the serological diagnosis of wheat-induced food allergy.
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