Abstract
Fujita and coworkers, utilizing 11C-(R)-rolipram positron emission tomography, demonstrate that human subjects with major depression exhibit reductions in the enzyme phosphodiesterase-4 (PDE4) in a number of brain regions (1). PDE4, a cyclic adenosine monophosphate (AMP) phosphodiesterase, is an important regulator of cyclic AMP concentrations in the brain; it has been suggested as a molecular target for antidepressant drug discovery (2). The present study provides support for this premise and also suggests that global reductions in cyclic AMP signaling in the brain may be associated with major depression.
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