Abstract
The response to epinephrine (EP) was determined for neurons in bullfrog sympathetic ganglia by intracellular and voltage-clamp recording techniques. EP (5 μM−1mM) produced a concentration-dependent depolarization mediated through β-adrenoreceptors. The EP-induced depolarization (EP D) was associated with a decrease in the membrane conductance. The EP-induced current (EP I) was decreased at hyperpolarizing potential levels and nullified at −70 mV. No reversal of the EP I polarity was seen. It is concluded that the EP D is generated by the suppression of a voltage-dependent g K, probably the M-channel 6.
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