Evidence for early presence of intestinal epithelial cell damage in multitrauma patients

J De Haan ,Luyer ,Borna Relja ,W A Buurman ,Tim Lubbers ,Joep P M Derikx ,J.w.m Greve ,Ingo Marzi

doi:10.1186/cc6357

Abstract

The present study investigates the presence of intestinal epithelial cell damage in multitrauma patients on admission. In trauma patients, the development of SIRS and sepsis are important determinants of clinical outcome. Intestinal damage is considered to play an important role in development of these inflammatory syndromes. However, clinical evidence remains scarce. Previously, in a rat model of hemorrhagic shock, we demonstrated that interventions reducing intestinal damage strongly attenuated the inflammatory response. In order to explore potential applicability of such therapies in trauma patients, the presence of early intestinal damage is assessed after trauma.

Highlights

The aim of this study was to elucidate the impact of ICU-acquired infection on ICU and hospital mortality
The goal from this study is to evaluate weaning predictor indexes in patients during weaning from mechanical ventilation (MV)
This study aims to evaluate the effects of the threshold in such situations

Summary

Introduction

The aim of this study was to elucidate the impact of ICU-acquired infection on ICU and hospital mortality. Methods A total of 48 community patients (36 men, 11 women, age 50.17 ± 17.974 years, APACHE II score 13.51 ± 6.153) who were expected to stay in the ICU for >5 days were included in this study. Specific examples of feedback are as follows: ‘good update of management plan reinforces need for taking into account concurrent medication when resuscitating patients’, ‘nice simple messages with good starting points for trying to deal with these complicated patients’, ‘useful data on risk of recurrence as this is a question often asked by patients’ This feedback was encouraging as it showed how the primary care professionals planned to change their practice to improve patient outcomes as a result of the learning. The course was considered excellent by 63% of the participants and good by 36%

Methods

Results

Conclusion