Abstract
1. 1. An imidazobenzodiazepine, Ro15-1788, has anticonvulsant effects in the kindling model for epilepsy. 2. 2. Ro15-1788 reverses the sedative actions of diazepam (3 mg/kg i.p.) but does not reverse the anticonvulsant effects. 3. 3. The anticonvulsant effects of Ro15-1788 are prevented by the pyrazoloquinolinone CGS-8216 which interacts with benzodiazepine receptors but has no anticonvulsant actions itself. 4. 4. It is suggested that Ro15-1788 is a partial agonist at the BZ 2 (anticonvulsant) receptor but is an antagonist at the BZ 1 (sedative, anxiolytic) receptor. CGS-8216 is an antagonist at both receptors. 5. 5. Ro15-1788 or related compounds may be effective anticonvulsants without the sedative side-effects usually found with the benzodiazepines.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Progress in Neuropsychopharmacology & Biological Psychiatry
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.