Abstract
We have recently developed a new technique designed to measure bulk flow of cerebral interstitial fluid (ISF) and, using this technique, have obtained evidence (1) supporting the classical view of cerebrospinal fluid formation by brain, i.e. of a slow “lymphatic” flow of ISF from brain to CSF via a perivascular canalicular system (2). This paper summarizes evidence suggesting bulk flow of ISF along the course of cerebral blood vessels and also presents new data showing transfer of radio-iodinated ( 131I) human serum albumin (RISA) from brain to CSF.
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