Abstract
Summary By use of a radioimmunoassay in combination with a variety of chromatographic separation procedures, evidence is provided for the existence of N-acetyl-leucine-enkephalin in the neurointermediate pituitary of the rat. N-acetyl-leucine-enkephalin accounts for ca. 20–25% of total leucine-enkephalin immunoreactivity. In the guinea-pig ileum bioassay, N-acetyl-leucine-enkephalin was found to be virtually opiate-inactive. This finding indicates that the process of N-acetylation in the rat pituitary is not restricted to β-endorphin and may be of general importance as a mechanism for the modification and/or inactivation of opioid peptides. In contrast to the neurointermediate pituitary, no N-acetylated derivative of leucine-enkephalin could be detected in the hypothalamus, striatum, midbrain and pons-medulla of rat brain.
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