Abstract
Studies were conducted to test whether parathyroid hormone-related protein (PTHrP) is able to stimulate adenylate cyclase activity in isolated rabbit glomeruli. Maximal stimulations were reached at 10 −7M of human PTHrP-(1–34) or rat PTH-(1–34) and showed a 3–3.3 fold increase over basal activity. The potency (EC 50) values were closed to 10 −9M. The guanyl nucleotide GTP, at 10 −5M, potentiated the effect of PTH and PTHrP but reduced their potency. The combined effect of maximal concentrations of PTHrP and PTH was not additive, and the PTH antagonist [Nle 8.18, Tyr 34]-bPTH-(3–34)amide inhibited both PTHrP- and PTH-stimulated adenylate activities. These findings suggest that PTHrP could affect glomerular function through changes in glomerular cAMP content by interaction with PTH receptors.
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