Abstract
Evidence for a biochemically demonstrable disturbance in the metabolism of vitamin B6during pregnancy is based on the following observations: (1) A marked increase of xanthurenic acid excretion following a tryptophan load test. (2) An abnormal excretion pattern of tryptophan metabolites on chromatographic analysis which is strikingly similar to that described in vitamin B6-deficient rats. (3) Immediate normalization of tryptophan metabolism following the administration of relatively small amounts of pyridoxine. (4) An abnormal vitamin B6, load test indicating a significantly larger retention of the administered vitamin in comparison to non-pregnant control subjects. Some patients with hyperthyroidism, febrile diseases, and carcinoma exhibit a similar disturbance of tryptophan metabolism which responds to the administration of pyridoxine. The possible mechanism of this disturbance is discussed and certain therapeutic implications are pointed out.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
