Abstract
Rat brain has been found to contain two forms of monoamine oxidase: an enzyme highly sensitive to the inhibitor clorgyline that acted on tyramine and serotonin (Type A); and an enzyme that was relatively insensitive to clorgyline and acted on tyramine but not serotonin (Type B). The superior cervical ganglion was found to contain about 90% Type A and 10% Type B enzyme. In contrast, the rat pineal gland contained 85% Type B and 15% Type A enzyme. After bilateral superior cervical ganglionectomy. Type A enzyme was barely detectable in the pineal gland. It is concluded that sympathetic nerves contain, almost exclusively, Type A monoamine oxidase.
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