Abstract
Under the influence of a Gardos channel activator, NS309, acting through an increase of the channels Ca 2+ sensitivity, it is found that the single population behavior of a suspension of human red cells, showing normal distributed osmotic resistance and density, after addition of NS309 in a time dependent manner changes to a two population distribution, with an increasing fraction of cells having high osmotic resistance or high density. The increase with time of the high resistance fraction can be fitted to an exponential, with a time constant corresponding to about 50 min. Since the ‘remaining’ cell fraction is practically unchanged, this points to a sudden random activation of the individual cells, caused by Ca 2+ entry through a channel like pathway.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.