Abstract
1. 1. The effects of nitroglycerol on cardiac muscle mechanics were studied in isolated left ventricular human papillary muscles. 2. 2. In isotonic afterloaded contractions nitroglycerol causes dose-dependent increases of the extent of shortening, of the velocity of isotonic contraction and relaxation and of the rate of tension development. 3. 3. Isotonic force-velocity relationships are shifted upwards and to the right with increases of both the maximum velocity of contraction (V max) and the maximum isometric tension (P 0). 4. 4. The results give evidence for a positive inotropic effect of nitroglycerol on isolated human ventricular myocardium.
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