Abstract
Lergotrile (0.5 mg/kg, i.p.) lowered blood pressure significantly in spontaneously hypertensive rats. This effect was antagonized by pretreatment with haloperidol, pimozide, or domperidone. In normotensive rats, administration of haloperidol or domperidone rapidly increased serum prolactin levels. Haloperidol also increased striatal levels of dihydroxyphenylacetic acid and homovanillic acid; however, domperidone did not, which confirms that this latter blocker probably acts primarily as a peripheral dopamine antagonist. Taken together, these data suggest that lergotrile lowers blood pressure in hypertensive rats mainly by stimulating peripheral dopamine receptors.
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