Evidence for a nonsense mutation at the niaD locus of Aspergillus nidulans.

Abstract

SUMMARYTwo mutations at theniaDlocus (structural gene for nitrate reductase apo-protein) are genotypically suppressible. Both mutations result in loss of nitrate reductase enzyme activity and cross reacting material and are non complementing, nonleaky and highly revertible. They have the properties of nonsense mutations. This implies that some of the allele specific suppressors, which act on these and alleles at several other loci, are nonsense suppressors.