Abstract
Summary Electrophysiological and biochemical studies have shown that the vertebrate neuronal somatic cell hybrid TCX11 expresses receptors for dopamine. Antiserum was produced in an effort to obtain an antibody to this dopamine receptor. Decomplemented antiserum reversibly blocked the electrophysiological dopamine response in TCX11. Two methods of purification yielded fractions which antagonized the response. The antiserum antagonized [ 3 H]-dopamine binding and the dopamine-sensitive adenylate cyclase in rat caudate homogenates. Dopamine responses were selectively blocked in the molluse Aplysia . These results suggest the presence of an antibody effective in altering dopamine receptor activity.
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