Abstract
Dopamine stimulated and dopaminergic antagonist·inhibited the enzymic synthesis of phosphatidyl N-monomethyl, N,N-dimethyl ethanolamine and phosphatidylcholine in mouse B lymphocytes in the presence of L-methionine. This effect was dose-dependent, stereospecific and the stimulation by dopamine was inhibited by very low doses of haloperidol from 10 −12 M to 10 −9 M. The stimulation of phospholipid methylation provoked by dopamine was increased by GTP. At higher doses DA inhibited and haloperidol stimulated phospholipase A 2. DA did not change the CDP choline pathway. The incubation of mouse B lymphocytes with L-methionine unmasks cryptic dopaminergic receptors. This effect is dose-dependent and inhibited by SIBA an inhibitor of phospholipid methylation. In a similar manner the efflux of Ca 2+ which is sensitive to the change in membrane viscosity was increased by DA. These findings indicate that the dopaminergic receptors of the mouse B lymphocytes are coupled with phospholipid methylation.
Published Version
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