Abstract
SummaryBile fistula patients were administered [14C]cholesterol and labeled mevalonic acid by constant infusion (for 5 hr) or by intravenous pulse. Bile was collected at frequent time intervals. The specific activities of newly synthesized cholic and chenodeoxycholic acids were virtually identical at all time periods (up to 24 hr). These observations provide evidence for the presence of a common cholesterol substrate pool for primary bile acid synthesis in man. Both cholic and chenodeoxycholic acids appear to be synthesized via the 7α-hydroxy-cholesterol pathway.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
