Abstract
The spermine-binding activity of a cytosol protein fraction from chick duodenal mucosa changes in relation to the circulating level of 1,25-dihydroxycholecalciferol. The spermine-binding activity increases very rapidly within 1–2 hours after the rachitic chick was dosed intracardially with 1,25-dihydroxycholecalciferol. The clear and reproducible response is prevented by actinomycin D and cycloheximide. This increase is one of the earliest events induced by the active form of vitamin D 3 in the duodenal cell of rachitic chicks.
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