Evidence for 2 types of noradrenaline storage particles in dog spleen.

Abstract

THE existence of different noradrenaline pools in sympathetically innervated tissues has been proposed on the basis of both pharmacological and biochemical studies1,2. Recent morphological evidence3,4, showing that the terminals of splenic nerves contain two distinct size populations of granulated vesicles and that only one of them is present in the preterminal processes, has given additional support to this theory. We now present biochemical evidence for the existence of two types of noradrenaline storage particles in the dog spleen and compare some of their properties with those of the noradrenaline vesicles of bovine splenic nerve.