Abstract
Through more than 40 years of reading, thinking, searching, and experimentation, we have found that the double helix model carries some defects or incorrect information. Evidence gleaned from the literature clearly indicates that the two strands of DNA are coiled ambidextrously, rather than plectonemically. It is likely that the linking number of native chromosomal Escherichia coli (E. coli) DNA is less than 960. Presently, a clear voice is necessary to break the ice formed from decades of misleading media, questionable textbooks, and expediency. For the sake of science, we are responsible and willing to share our hard-earned knowledge, experience, and knack with the public. A promising research plan is provided for the additional falsification of the right-handed double helix model. It would be a precision hit at the Achilles’ heel of the double helix model. An appropriate conceptual shift will hopefully lead to new knowledge on the secondary structure of DNA and improve understanding of its biological functions.
Highlights
IntroductionThe Proposal of the Double Helix Model is a Great Progress in Molecular Biology
Starting more than 40 years ago, we focused our attention on the untangling of the double helix
(d) McKay and Steitz [29] demonstrated that the structure of the catabolite gene activator protein (CAP) at a resolution of 2.9 Å using X-ray crystallography fits left-handed DNA
Summary
The Proposal of the Double Helix Model is a Great Progress in Molecular Biology. Starting in 1869, Miescher found a relatively pure sample from pus His further analysis made it clear that it contained lots of phosphorus and it was different from carbohydrates or protein. Just as Crick et al stated: “DNA is such an important molecule that it is almost impossible to learn too much about it.” [1]. Depending on the base pairing, DNA fiber X-ray analysis, model building, and the information available at that time, Watson and Crick proposed a hypothesis in 1953 [2]. The self-replicating ability of the double helical structure of the DNA molecules aroused great interest and excitement. The finding of the double helix is no doubt a milestone in DNA investigation and it is a great progress in molecular biology. Anyone daring to argue the validity of the double helix may be deemed as committing blasphemy against modern science
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