Abstract
Traditional practice has dictated that solutions with an osmolality of 600 to 900 mOsm/L, such as intravenous (IV) antibiotics, be administered via the intravenous piggyback (IVPB) route. This practice is due to concern for phlebitis, local irritation, and infiltration during peripheral administration of hypertonic solutions. IV cephalosporins, when reconstituted with 0.9% sodium chloride injection, have an osmolality ranging from 575 mOsm/L with ceFAZolin to 1040 mOsm/L with Cefepime1 and subsequently fall into the category of solutions with an osmolality high enough to be of concern.
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