Abstract
The quality and life expectancy of the population depends on the level of access to modern, high quality, effective and evidence-based medical and pharmaceutical care. These types of care play a significant role in the pharmacotherapy of cardiovascular diseases, which are one of the main medical, biological and socio-economic problems of society. The main nosologies that cause high mortality from cardiovascular disease are heart attacks, strokes, sudden death syndrome and cardiomyopathy, which are preceded by such pathological conditions as hypertension, life-threatening arrhythmias, angina, chronic venous insufficiency. The aim of the study was to obtain and study aescine from the amniotic fluid of Aesculus hippocastanum L. The pericarp of the plant Aesculus hippocastanum L. as a source of aescine was studied. As a vegetable raw material for the production of aescine we used amniotic horse chestnut. A new method for the isolation of aescine by its extraction from horse chestnut n-butanol saturated with water, followed by purification of the target product with aluminum oxide. The amniotic fluid of horse chestnut on the content of aescine were studied. Found that the content o in this raw material ranges from 1.5% to 2.5%.
Highlights
The quality and life expectancy of the population depends on the level of access to modern, high quality, effective and evidence-based medical and pharmaceutical care. These types of care play a significant role in the pharmacotherapy of cardiovascular diseases, which are one of the main medical, biological and socio-economic problems of society
The main nosologies that cause high mortality from cardiovascular disease are heart attacks, strokes, sudden death syndrome and cardiomyopathy, which are preceded by such pathological conditions as hypertension, lifethreatening arrhythmias, angina, chronic venous insufficiency
A new method for the isolation of aescine by its extraction from horse chestnut nbutanol saturated with water, followed by purification of the target product with aluminum oxide
Summary
The quality and life expectancy of the population depends on the level of access to modern, high quality, effective and evidence-based medical and pharmaceutical care. Хронічна венозна недостатність є не тільки косметичною проблемою (варикотромбофлебіти, трофічні порушення шкіри, виразки) значно знижують працездатність, порушують соціальну адаптацію і якість життя хворих, а також можуть привести до ССЗ (інсульт, інфаркт міокарда, тромбоемболія легеневих артерій), які чреваті летальним результатом. Універсальних лікарських засобів для фармакотерапії хронічна венозна недостатність дотепер не створене. Перспективною фітосировиною для розв'язання поставленого завдання є насіння кінського каштана звичайного – джерело есцину. Батьківщиною каштана кінського (Aesculus hippocastanum L.) є Балканський півострів.
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