Abstract

To evaluate the quality of oocyte cohorts retrieved from healthy young women undergoing repeated cycles of oocyte donation. Retrospective cohort study. Records of oocyte donation cycles performed at a single ART center from November 2011 through April 2019 were reviewed. The associations between oocyte donation cycle number and pre-treatment antral follicle count (AFC), total dosage of follicle-stimulating hormone (FSH) administered during ovarian stimulation, days of ovarian stimulation, follicles > 14 mm at trigger, retrieved oocyte number, mature (MII) oocyte number, the number of good quality blastocysts, and the percentage of euploid blastocysts among cycles undergoing PGT-A analysis by NGS were evaluated by linear regression analysis. A total of 91 oocyte donation cycles among 18 oocyte donors (3 to 6 cycles each) were available for analysis. The total dosage of FSH administered per cycle remained constant across treatment cycle numbers. However, a higher number of prior oocyte donation cycles was associated with significantly increasing numbers of antral follicles, mature follicles (>14mm) at trigger, and mature (MII) oocytes retrieved. Our investigative efforts focus on providing more couples the opportunity to have healthy children. One such group is egg donor recipients. There are limited available data on repeated ovulation stimulation cycles. It has been suggested that FSH stimulation may hasten ovarian aging by increasing recruitment of small growing follicles, thereby accelerating the depletion of follicle reserve. It has not been reported if repetitive oocyte donation affects average follicles recruited, oocyte maturity, blastocyst rate or ploidy status.

Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call