Abstract
To the Editor: In our recent publication,1 we argued that intracellular calcium (Cai) dynamics is not an essential mechanism of the maintenance of ventricular fibrillation (VF). Our argument was based on 2 major observations: (1) Cai transient passively followed the optical action potential along the entire wavelet span, except at the very wavelet tip; and (2) chelating Cai with BAPTA-AM did not change the incidence of wave break (WB) during VF. In their letter to Circulation Research , Ogawa et al2 raised a concern that our BAPTA test is not valid because the time of BAPTA perfusion in our experiments (≈10 minutes) was too short to achieve a significant effect. To support this statement, Ogawa et al referred to their own (unpublished) results in Langendorff-perfused rabbit hearts indicating that after 30 minutes of perfusion with 20 μmol/L BAPTA-AM, rapid pacing …
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