Abstract
Summary In isolated intact superior cervical ganglia of the rat dopamine is able to increase the levels of adenosine 3′, 5′-monophosphate (cAMP) only if used in concentrations about two orders of magnitude higher than norepinephrine or epinephrine. The methylxanthines papaverine and theophylline have no or liminal effects on cAMP levels in control ganglia or ganglia incubated with dopamine. However, papaverine potentiates the norepinephrine-induced accumulation of cAMP both in ganglia and incubation media. Repeated incubations with norepinephrine in the presence of papaverine show a rapid decrement of the response and a sustained fall of cAMP in ganglia and media. The catecholamine induced rise was blocked by β-, and partially inhibited by a-adrenergic antagonists.
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