Abstract
We applied the Everyday Cognition (ECog) scale in normal aging adults and patients with Alzheimer’s disease (AD) to investigate associations between neuropsychological tests and neuroimaging markers. A total of 160 normal aging adults and 40 patients with the early stage of probable AD were included. Neuropsychological performance was assessed using the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Assessment Battery (CERAD-NAB). 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) scans were used to measure AD-related hypometabolism. Nonparametric Spearman correlation analysis was used to study associations between ECog and z-transformed total CERAD-NAB scores in both groups. The results revealed a significant correlation between total ECog and CERAD-NAB scores (rho = −0.28, p < 0.01), and category verbal fluency test with the executive domain of the ECog scale (rho = −0.20, p < 0.01). The CERAD-NAB scores were also significantly correlated with AD-related hypometabolism (rho = −0.49, p < 0.01). The memory domain of the ECog scale was significantly correlated with FDG uptake in the angular gyrus and posterior cingulum gyrus (rho = −0.41 and −0.46, P < 0.01). In conclusion, both total and memory domain ECog scores were correlated with the neuropsychological tests and neuroimaging biomarkers.
Highlights
Of the dementia syndromes, Alzheimer’s disease (AD) is the most common degenerative form
The results revealed that the total and average Everyday Cognition (ECog) scores were significantly associated with the neuropsychological test scores
We demonstrated that the ECog scale could differentiate patients with the early stage of probable AD from normally aging adults
Summary
Alzheimer’s disease (AD) is the most common degenerative form. The Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Assessment Battery (CERAD-NAB) is a well-validated, widely used tool to study cognitive deficits in patients with dementia[13, 14]. It has been translated into several languages including German, Finnish, and simplified and traditional Chinese for use in Hong Kong, China and Taiwan[15,16,17,18,19,20]. We investigated associations among the ECog scale, CERAD-NAB and FDG-PET scans in the early stage of probable AD.
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