Abstract
In this contribution, we demonstrate the feasibility of fluorescence single-molecule localization microscopy (SMLM) imaging with an event-based (or neuromorphic vision) sensor. Event-based sensors are matrices of independent pixels sensitive to intensity variations only, with a microsecond range temporal resolution. We have integrated such an event-based sensor in a typical SMLM set-up and characterized its localization precision and response linearity. We obtain super-resolution images of biological samples of the same resolution than with conventional scientific cameras. Finally, we exploit the unique characteristics of event-based SMLM to perform high-density acquisitions with overlapping PSFs, achieving much better results than with frame-based cameras.
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