Event-related slow potentials evoked during ankle jerk conditioning in wakefulness and NREM sleep

Abstract

Slow cortical potentials related to the ankle jerk and to its conditioning were studied in 40 adults while awake and during NREM sleep. A weak sound (S) was used as conditioned stimulus, while the ankle jerk, evoked either by Achilles tendon percussion (P) or by electrical stimulation of the sciatic nerve (H), served as unconditioned or ‘imperative’ stimulus. During waking, responses to simple stimuli (S, P, H) were mostly negative. During S-P and S-H pairs, responses to S were mainly negative, resembling the CNV, while these to P or to H became mostly positive, like the CNV resolution or the positive phase of the motor potential. During NREM sleep, responses to simple as well as to paired stimuli showed mostly a biphasic (negative-positive) morphology resembling the K complex. The conditioned slow potential changes obtained by pairing a sound with the ankle jerk therefore seem to be abolished during NREM sleep. This absence of conditioning can be related to the absence of habituation during NREM sleep. In 35% of the cases, however, positive slow waves were evoked by paired sounds during sleep. The possible significance of these phenomena is discussed.