Abstract
Background and Aims: Familial hypercholesterolemia (FH) is a genetic disorder characterized by lifelong elevated low-density lipoprotein cholesterol (LDL-C) and premature coronary heart disease (CHD). Cholesterol-lowering therapy (statins) reduces CHD risk, but have only been available for the last 25 years, thus, elderly (>65 years) FH patients have been untreated several decades of their life. Surprisingly, some of these have never experienced any CHD event, raising the question whether they present CHD-resistant characteristics. To our knowledge, there are no reports of comprehensive metabolite profiling in these individuals. Therefore, we aimed to characterize metabolic differences between elderly FH subjects with and without CHD.
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