Evans syndrome: A case report

Abstract

Evans syndrome is described as the simultaneous presence of immune thrombocytopenia, warm autoimmune haemolytic anaemia, and sometimes autoimmune neutropenia. It occurs due to autoantibodies that fail to cross-react with antigens unique to platelets, red blood cells, or neutrophils. Haemolysis and thrombocytopenia may be causing clinical symptoms. Evans syndrome stands as a rare condition diagnosed through a process of exclusion. Initial treatment options encompass intravenous corticosteroids or intravenous immunoglobulins, serving as the first choice of interventions. In cases where patients do not respond to steroids, the subsequent steps involve second-line treatments such as rituximab or splenectomy. A 43-year-old female with a history of Evans syndrome presented with a complaint of generalised weakness for 20 days after having recently been tapered off of prednisone. She was treated with a combination of immunomodulators and corticosteroids. Here, we try to highlight the importance of medication adherence which is essential in treating chronic disorders.