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Abstract
Evaluations of Potential Antiviral Effects of Green Zinc Oxide and Silver Nanoparticles against Bovine Herpesvirus-1
Highlights
Bovine alpha herpesvirus-1 (BoHV-1) belongs to Varicellovirus genus under the family Herpesviridae, BoHV-1 is a highly contagious viral disease which causing infectious bovine rhinotracheitis in cattle (Biswas et al, 2013; Ranganatha et al, 2013)
The results showed two absorption peaks at wave- length about 340 and 630 nm were were attribute to the formation of AgNPs or ZnONPs
The cell viability results with different AgNPs and ZnONPs concentrations (μ g/mL) Ag-Ps and ZnONPs were mild cytotoxic effect on Madin Darby Bovine Kidney (MDBK) cell culture at 10 to 50 μg /mL concentration but they had cellular toxicity with different degrees with higher concentration more than 60 μg /mL as in Table 2 demonstrated that the cytotoxic effects of different concentration from silver, zinc oxide nanoparticles and Acyclovir on MDBK cells ranged from 60 to 900 μg / mL
Summary
Bovine alpha herpesvirus-1 (BoHV-1) belongs to Varicellovirus genus under the family Herpesviridae, BoHV-1 is a highly contagious viral disease which causing infectious bovine rhinotracheitis in cattle (Biswas et al, 2013; Ranganatha et al, 2013). There are no antiviral agents available capable of complete elimination of viral infection and facilitating recovery from latent infection. BoHV-1 is used for disease model to improve control strategies against herpesviruses infection in human and animals (Rasheed et al, 2018). Necessary developing antiviral agents targeting on infected cells for clarification from infectious virus in host organs, in reservoir which spreading virus throughout animal herds (Xu et al, 2018). The available synthetic drugs possess several disadvantaged including toxicity and developed drug resistance (Chou and Lurain, 2019)
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