Evaluation the relation between age at the time of diabetes diagnosis and Glutamic acid decarboxylase (GAD) antibody in non- overweight, obese diabetic individuals

Abstract

Objective: Evaluation the relation between age at the time of diabetes diagnosis and glutamic acid decarboxylase (GAD) antibody in non- overweight, obese diabetic individuals. Method: A cross-sectional study on 284 non overweight- obesity diabetic patients at Hue Central hospital from August 2017 to August 2019. All patients were measured autoantibodies glutamic acid decarboxylase (anti-GAD). GAD antibody- positive was determined when autoantibodies to GAD concentration was higher than 5 IU/mL. Clinical data (age, sex, weight, hight) were obtained. Age at the time of diabetes diagnosis was interviewed. Data were analysed by SPSS version 16.0 and Medcalc software. Results: The risk of glutamic acid decarboxylase (GAD) antibody- positive in non- overweight, obese diabetic individuals increased 2.7 time when aged at the time of diabetes diagnosis 50 and older. The cut-off of age at the time of diabetes diagnosis for detecting risk of glutamic acid decarboxylase (GAD) antibody- positive in non- overweight, obese diabetic individuals was 57. Conclusion: This study showed non- overweight, obese diabetic individuals should be screened for glutamic acid decarboxylase (GAD) antibody at aged 50 and older