EVALUATION THE LIVER FIBROSIS BY TRANSIENT LIVER ELASTOGRAPHY COMPARING TO LIVER ANAPATHOLOGY IN CHRONIC HEPATITIS

Abstract

Background: Transient elastography (FibroScan) is a novel, noninvasive, safe and rapid bedside method, in assessement the liver stiffness in chronic hepatitis. Aims: To assess the degree of liver fibrosis in the chronic hepatitis patients in comparison with liver biopsy performed at the same time. Methods: We studied 66 consecutive patients with chronic hepatitis, in which liver stiffness was measured by FibroScan and liver biopsy was performed in the same session (assessed according to the Metavir score). Results: FibroScan values ranged from 3.8 to 75 kiloPascal (median, 16.46 kPa). According to the Metavir score of the 66 patients: 22,1% had F0 and F1, 12 had F2, 16.6% had F3 and 43,9% had F4. The mean values of liver stiffness in patients were: F0 & F1: 5.35 ± 2.73 kPa; F2: 8.59 ± 3.37 kPa; F3: 12.45 ± 4.69 kPa; F4: 32.44 ± 18.52 kPa. There were the significant positive correlation between the liver stiffness measured by FibroScan and liver biopsy (r = 0.6, p < 0.05). Conclusions: FibroScan is a simple and effective method in assessing liver fibrosis. The liver fibrosis measured by FibroScan was well correlated with the degree of liver fibrosis by Metavir index, serum albumin, bilirubin, AST, platelet, INR in chronic hepatitis. Keywords: Chronic hepatitis, Fibrosis, Transient elastography, Liver biopsy