Abstract

 Genetic material is the most important component of cells because it contains the genetic information; hence any disruption to the structure chromosome of cells could lead to very bad results. Genotoxicity use to evaluate the safety of any chemical compounds on genetic materials. Artificial food flavoring additive are chemical substances to produce specific placebo effects added to foods but impart specific flavor to it.
 The present study evaluates the genotoxic effect of artificial food flavoring additive on structure of chromosomes at three different concentrations (50%, 100%and 150%) on both bone marrow cells and spleen cells in mice for fourteen successive days. It was found that artificial food flavoring additive at concentration (50% and 100%) show not significant increase in total chromosomal aberration in both bone marrow cells and spleen cells when compare to negative control (p>0.05) meanwhile at concentration 150% it causes a significant increase when compare to negative control (p<0.05) .The results have been showed that artificial food flavoring additive had a genotoxic effect at (50%, 100% and 150%).
Highlights
Artificial food flavoring additive is chemical substances to produce specific flavor when added to foods [1]
In table [1],in bone marrow cells, artificial food flavoring additive at concentration 50% show not significant increase in total chromosomal aberration, chromosomal break, chromosomal gap and ring chromosome when compared to negative control (p>0.05) the rest individual chromosomal aberration show a significant increase at same concentration when compare to negative control (p
At concentration 100% artificial food flavoring additive show non-significant increase in total chromosomal aberration, chromosomal break and ring chromosome when compared to negative control(p>0.05), the rest individual chromosomal aberration show a significant increase at same concentration when compare to negative control (p0.05)
Summary
Artificial food flavoring additive is chemical substances to produce specific flavor when added to foods [1]. There is huge orientation for use different types of food additive to the foods [2]. Food additives and their metabolites are subjected to different types of toxicological analysis before marketing [3]. A previous study shows that about 75% of the Western diet is made up of different types of processed foods; it has been show that the individual consume 8-10 pounds of food additives per year [4]. The children considered as the higher consumer for the food with these food additive [5]. The DNA in a human cell undergoes several thousand to a million damaging events in every day which most of them are detected by repair system [11]
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Schedule a callMore From: Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512)
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