Evaluation the Efficacy of Vitamin D Consumption on Nephrotic Syndrome Condition in Children: A Clinical Trial Study

Abstract

Background: Vitamin D may have a beneficial effect on the kidney tissue and in children with nephrotic syndrome. Objectives: The aim of this study was evaluation the efficacy of vitamin D consumption on nephrotic syndrome condition. Methods: This assessment is a clinical trial study in which 30 patients with nephrotic syndrome were included in the study. In addition to the usual treatment of nephrotic syndrome, vitamin D injections were also used, in which vitamin D was administered as a 300,000 unit ampule, with a volume of one cc, dissolved in 5 cc of olive oil and injected. Two months later, the level of vitamin D and the nephrotic syndrome status was evaluated and the two indicators were compared. Results: Mean and standard deviation of the age was 3.05 ± 9.37 years, 16 patients (53.3%) were male and 14 cases (46.7%) were female. Regarding the response to treatment, 3 patients (20%) had mild, 10 patients (66.6%) had moderate and 2 patients (14%) had severe nephrotic syndrome. In the group with normal levels of vitamin D, 3 patients (20%) had mild, 11 (73.3%) patients moderate and 1 patient (6%) had severe nephrotic syndrome. Conclusions: Based on our results, vitamin D consumption did not have a considerable effect on improving the clinical status of patients with nephrotic syndrome.