Evaluation the Effects of Foeniculum vulgare Essence on Behavioral-Motor Disorders of Parkinson’s Disease induced by Reserpine in Ovariectomized and Non Ovariectomized Rats

Abstract

Background: Parkinson's disease (PD) is a common disorder that causes damage to the central nervous system. It mainly affects the motor system and is generally diagnosed with the loss of dopaminergic neurons. Fennel plant (Foeniculum Vulgare Mill) belongs to the flowering plant of the fennel Apiaceae family. It is a medicinal plant that is commonly used by the tribes in Iran. Fennel plant has an estrogenic effect. Objectives: The intention of this study was to analyze the effects of various doses of foeniculum vulgare mill essence on behavioral motor dysfunction in reserpine-induced model of PD in ovariectomized and non ovariectomized rats. Methods: To create a model of Parkinson’s drug reserpine subcutaneously at a rate of 3 mg was used. Rats were surgically ovariectomized. Ten groups, each consisting of 8 rats, were used. The authors studied a total of 48 ovariectomized rats. Essential oil of fennel (50,100,200 mg/kg) were used for treatment for 5 days. After the 5 days of behavioral and motor tests were performed, the amount of estrogen was measured. Results: In this study, rats were ovariectomized and fennel essential oils doses (50, 100, 200 mg/kg) significantly increased amounts of estrogen. The motor disorders of the treated groups were reduced. Furthermore, the non-ovariectomized groups were treated with essential oils of fennel. The amount of estrogen increased and motor activity as well as behavior had improved in the control groups. Conclusions: The present study affirms that essential oils of fennel improve Parkinson’s in animal models. Further studies are needed to demonstrate the possible effects of essential oils of fennel on individuals with Parkinson’s and postmenopausal women.