Evaluation the Effect of Interleukin-6 and Tumor Necrosis Factor in Semen Quality of Infertile Men with Varicocele.

Abstract

Objective: The study was designed to evaluation of effect Interleukin-6 and Tumor necrosis factor in seminal plasma to semen quality in infertile men with varicocele. Methods: A descriptive correlation study was conducted in specialized infertility center / teaching AL-Sadder medical city in Najaf city from first of April 2014 to the first of June 2014.Sample was selected that consisted of (75) infertile men with varicocele, and (25) healthy subject as control, their age between (20-40) years old. A questionnaire format and observational checklist were used which including marriage period, excluding from chronic disease like diabetic, cancer, sexual transmitted disease. The data were collected through the utilization of questionnaire and the structure interview technique with varicocele patients. Data was analyzed by using T-test and Z-test Results: The result of the study sample have revealed that 42% from all subjects has elevated Interleukin-6 concentration in seminal plasma ,and also the elevation Interleukin-6 level in seminal plasma has inversely correlation R = -0.58 with decreased in sperm motility ,also has inversely correlation R = -0.30 with low sperm count. From other hand 41% from all subjects has elevated Tumor necrosis factor levels in seminal plasma ,and also the elevation Tumor necrosis factor concentration in seminal plasma has inversely correlation R = -0.17 with decreased in sperm motility ,also has inversely correlation R = -0.25 with low sperm count. Conclusions: They study concluded there was a significant difference between elevation of Interleukin-6 and Tumor necrosis factor levels in seminal plasma in infertile men with varicocele, and they study concluded there was a significant correlation between increased levels of Interleukin-6 and Tumor necrosis factor in seminal plasma with reduce sperm count and motility . Recommendations: the study recommended that: Varicocele examination and diagnosis should be done to all infertile male. Varicocele patients with abnormal seminal fluid examination should be estimated concentration of Interluekin-6 and Tumor necrosis factor in seminal plasma