Abstract
The aim of our research was to investigate the probable preventive effect of lipoic acid in fertility of rats against gentamicin toxicity. Twenty four male rat divided into four groups each group have 6 animals were treated as follows: untreated control animals (group1), treated with lipoic acid 600 mg/kg orally (group 2), treated with gentamicin 80 mg/kg intraperitonialy (group 3) & treated with lipoic acid combination with gentamicin (group 4) all these groups treated for four weeks. The result revealed physiological & histopathological changes in animals treated with gentamicin, there are significant decrease in testosterone & LH levels, also there are significant decrease in sperm count, viability, motility & significant increase in sperm abnormality. On the other hand, lipoic acid when given with gentamicin lead to return all these alteration near closely to the normal states. In conclusion, lipoic acid causes enhancement the alteration induced by gentamicin in male reproductive system of rat.
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