Abstract
The high-density gastroretentive dosage forms was made a high-density theophylline tablets 250 mg by wet granulation method in three formulas with combine the polymer concentration. The polymer used sodium alginate and PVP K30, where the 1st formula ratio of sodium alginate: PVP K30 (18.75%: 5%), the 2nd formula ratio of sodium alginate: PVP K30 (18.75%: 2, 5%) and 3th formula ratio of sodium alginate: PVP K30 (12.5%: 2.5%). The third formula were evaluated with weight uniformity test, size uniformity test, hardness test, drug content test, in vitro release test, as well as the determination of the kinetics of drug release. The result showed the uniformity weights of the formula ranges 250.12mg-250.70mg, the uniformity size of the formula ranges 0.81cm for diameter tablet and 0.42cm-0.44cm for thick tablet, the hardness test ranges from 90N-180N. Results obtained for drug content was 106.965% formula 1st, formula 2nd is 127.625% and for formula 3th is 115.976%. Release kinetic profiles show formula 1st and 2nd used Higuchi equation and formula 3th used the first-order equation. By these three formula, 1st formula was considered the best views of drug content and release kinetics.
Highlights
Drugs is a chemical substance, typically of known structure
One tablet of each formula was taken and ground until smooth and sonicated in 100 mL of 0.1 N HCl solution pH 1.2 for 5 minutes the absorbance was measured on a UV-Vis spectrophotometer at a wavelength of 269.45 nm which was obtained from the determination of the wavelength. maximum wave
The sample obtained was diluted by pipetting 0.8 mL of the sample using a micropipette and the volume was made up to 10 mL and the absorbance was measured on a UV-Vis spectrophotometer at a wavelength of 269.45 nm which was obtained from the determination of the maximum wavelength
Summary
Drugs is a chemical substance, typically of known structure. Drug used for diagnosis, reducing pain, and treating or preventing disease in humans[1]. The oral route is generally considered an ideal drug delivery system which will have two main properties namely it must be in a single dose to prolong the action and must deliver the active drug ingredients directly to the target site[3]. In conventional oral drug delivery systems there is no control over drug release and effective concentration of overdosage[4] changing dosage patterns can cause side effects in some cases[5]. The rate and extent of drug absorption from conventional drug formulations can be different, depend on the factors such as the physicochemical properties of the drug, the presence of additives and various physiological factors such as the presence or absence of food and the pH of the gastrointestinal system[6]
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