Evaluation on the therapeutic effects of hyperbaric oxygen coupled with vancomycin in the treatment of staphylococcus aureus infective endocarditis

Abstract

Objective To explore the clinical effects of hyperbaric oxygen (HBO) coupled with vancomycin in the treatment of staphylococcus aureus infective endocarditis (SAIE). Methods Eighty-eight SAIE patients who received treatment in the department of cardiovasology of the hospital from January 2015 to January 2017 were recruited as study subjects and were divided into the observation group and control group according to different treatment methods. In addition to routine treatment, the control group was given vancomycin, while the observation group received HBO therapy on the basis of the treatment received by the control group. After treatment, therapeutic efficacy, bacterial negative turn rate, rate of adverse reactions and the expression levels of related serum cytokines (IL-6, IL-8, IL-10, VEGF, TNF-α and IFN-γ) were compared between the 2 groups The efficiency, rate of adverse reactions and related serum cytokines levels (IL-6、IL-8、IL-10、VEGF、TNF-α、IFN-γ) were compared between the 2 groups. Results The therapeutic efficacy and bacterial negative turn rate of the observation group were respectively 63.6% and 72.7%, which were significantly higher than those of the control group, and statistical significance could be seen when comparisons were made between the 2 groups(P 0.05). The expression levels of serum IL-6, IL-8 and VEGF were significantly lower than those of the control group, with statistical significance(P<0.05). Conclusions HBO therapy could augment the efficacy of vancomycin in the treatment of SAIE, and this treatment profile has its important value in clinical practice and is worth further clinical promotion. Key words: Hyperbaric oxygen; Vancomycin; Staphylococcus aureus; Infective endocarditis