Evaluation on protective efficacy of different doses of hepatitis B vaccine combined with hepatitis B immune globulin in preventing mother-to-infant transmission of hepatitis B virus

Abstract

Objective To evaluate the protective effect of 10 μg and 20 μg hepatitis B vaccines combined with hepatitis B immune globulin (HBIG) in preventing mother-to-infant transmission of HBV.Methods One hundred and twenty-four infants whose mothers were HBsAg positive were randomly divided into two groups,i.e.10 μg and 20 μg hepatitis B vaccine group.Hepatitis B vaccine at 10 μg or 20 μg dose was inoculated on 0,1,6 month schedule with administration of 200IU HBIG at birth and 1 month.Serum HBV markers of the infants were detected at birth and 12 month.Results At birth,the positive rates and levels of serum HBsAg,HBeAg and anti-HBe in 124 infants between the two groups had no significant difference(P ＞0.05),serum HBV DNA was not detected.At 12 month,serum HBsAg,HBeAg and HBV DNA in 124 infants were negative; the positive rate of anti-HBs was 90.3％ and 96.8％ (P ＞ 0.05) ; the level of anti-HBs was 325.5 ± 342.2 mIU/ml and 463.7 ± 353.3 mIU/ml(P =0.01) in 10 μg and 20 μg hepatitis B vaccine group,respectively.The rate of more than 100 mIU/ml anti-HBs in 20 μg hepatitis B vaccine group was significantly higher than that in 10 μg hepatitis B vaccine group(P =0.035).Conclusion Administration of 20 μg hepatitis B vaccine combined HBIG has better effect on preventing mother-to-infant transmission of HBV than that of 10 μg hepatitis B vaccine combined HBIG. Key words: Hepatitis B virus; Disease transmission, vertical; Hepatitis B vaccine; Immune globulins; Immunity, active