Evaluation on clinical therapeutic efficacy of compound alverine citrate and clostridium butyricum on irritable bowel syndrome

Abstract

Objective To observe and evaluate the efficacy of compound alverine citrate with capsule of clostridium butyricum live in the treatment of IBS. Methods 81 patients with IBS were divided into 2 groups randomly. Patients in group A (41 cases) were treated orally with capsule of compound alverine citrate (Meteospasmyl, one capsule, 3 times a day) and capsule of clostridium butyricum live (Ataining, 1.26, twice a day),while those in group B (40 cases) were given orally pinaverium bromide (Dicetel, 50 mg, 3 times a day) for 4 weeks. A observation and evaluation on the change of such symptoms as abdominal pain, abdominal bulge, diarrhea, or constipation was performed respectively at the end of 2nd and 4th week of therapeutic period. Results The total effective rates were 70.7% and 88.6% at the end of 2nd and 4th week of the medication period respectively in group A, and those in group B were 65.0% and 81.8% simultaneously. There was no significant difference (P>0.05) between the efficacy of group A and B, neither after 2 weeks' treatment nor after 4 weeks' treatment. However, at 2nd week, the improvement of abdominal bulge symptom in group A was better than in group B (P<0.01). Conclusions Compound alverine citrate and capsule of clostridium butyricum live can be used in the treatment of IBS with a definite therapeutic effect. Key words: Compound alverine citrate; Meteospasmyl; Clostridium butyricum; Pinaverium bromide; Irritable bowel syndrome