Evaluation on Antisperm Antibody in Infertile Men with Oligoasthenoteratozoospermia

Abstract

Objective To evaluate the level of antisperm antibody (ASA) in infertile men with oligoasthenoteratozoospermia (OAT). Methods Forty-six infertile men with OAT were enrolled into this study. Sperm samples were screened by the direct immunobead test for ASA type IgG and IgA according to the WHO laboratory manual. Results Of the 46 patients with OAT assessed for ASA-IgG, 2 had immunobead binding which were 22% and 27%, respectively, and the sub-positive rate was 4.3%. No case had the clinical positive level according to the WHO criteria (≥ 50% of the motile sperm with immunobead binding). ASA-IgA was not detected in all cases. Conclusion A significant incidence or high level of ASA could not be found in infertile men with OAT, which suggests that ASA is not associated with the pathogenesis of infertile men with OAT.